Aspirin is now the most widely used drug for pain relief in the world. Around 100 billion tablets are taken every year. Salicylic Acid is a substance that helps reduce pain in the body’s never-ending. Ancient Greek people used willow bark tree, which is rich in Salicylic acid more than two thousand years ago. However, it tasted awful and could cause vomiting and stomach pain. In 1897, German chemist, Felix Hoffmann produced Acetylsalicylic acid which caused fewer side effects but still and effective pain reliever. German Chemical company Friedrich Bayer and CO began selling ASA in 1899 under the brand name Aspirin.